Posted by psychobot5000 on January 17, 2007, at 17:29:21
In reply to Re: amineptine/tianeptine for depression, posted by elanor roosevelt on January 17, 2007, at 11:55:09
The only contraindicated drugs for tianeptine are MAOis, but this is not due to a known danger--only to inadequate research on the subject. Tianeptine actually has been combined with MAOis, SSRIs, and definitely stimulants, safely. There really isn't enough literature on the drug to know whether it's absolutely safe, but on the other hand, there is little reason why not to.
The dopaminergic (and possibly the antidepressant) effects of tianeptine do not seem to be dependent on its effect on serotonin--there is not enough research into what happens when combining it with an SSRI, but it has been done without safety issues, and some people on this board (and at least one case report) claim an augmented response using the two together.
According to my experience, tianeptine does not seem to interact with stimulants--the effects seemed additive, but do not seem to directly interact (i.e. they didn't modify, potentiate, or block each other as far as I could tell). I found the combination useful for treatment-resistant depression, though the side-effects of the stimulants (sleep disruption, heart-rate) ultimately led me to drop them from my regimen. Since tianeptine usually is not motivating or stimulating, stimulants seem natural drugs to combine with it in treating treatment-resistant depression. With SSRIs...it's hard to know (from theory and pharmacology) what ought to occur when combining with tianeptine, but the result does -not- seem to be that they block each others' effects (from the little clinical evidence available), though that would theoretically be a possible result.
Best of luck,
p-bot
poster:psychobot5000
thread:611
URL: http://www.dr-bob.org/babble/20070113/msgs/723331.html