Posted by yxibow on January 16, 2007, at 1:54:02
In reply to Re: I Don't Get Lyrica, posted by Reggie BoStar on January 15, 2007, at 23:46:28
> If it is like super-Neurontin as med_empowered said, you may want to look into Gabitril as well.
>
> In my experience Gabitril is a **very** potent GABA-reuptake inhibitor (SGRI)and has to be taken with caution - especially in combination with Neurontin. I take 8mg/day, in 2, 2, and 4mg doses spread out over the day.
>
> I use it to prevent migraines, which it does very well. It is also supposed to treat GAD but it doesn't help me much there. I take Buspar for the GAD.
>
> The upside is that even small doses of Gabitril noticeably enhance my cognitive function, memory, and motivation. Right now the latter effect is being masked by Lamictal, but I suspect that will change the next time I leave a heated message for my pdoc.
>
> The downside is that even slightly larger doses like 12mg can cause symptoms of GABA toxicity, which have to be experienced to be believed. For me, they included very poor coordination, panic, and bizarre visual disturbances (constantly changing areas of blindness, and visual "trails" left behind by moving objects). However, this could be a complication of the combination with Neurontin, which I am taking at a dose of 1800 mg/day in three doses of 600 mg spread through the day.
>
> The upside effects make Gabitril well worth taking for me. And NO migraines either!
>
> BTW this is another indication that a migraine may be a type of seizure. Reduction in the frequency of seizures is really what one of the purposes of Gabitril is.
>
> If the other stuff is creeping you out, check out Gabitril. At least it's been around and has a proven track record.
>
> Good luck,
> Reggie BoStar
Though you'd think that Gabitril as an AED would reduce seizures, too much GABA action can also create seizures as well. Gabitril (tiagabine) carries a possibility of causing seizures in non-epileptic patients and should be treated cautiously.That's what the caution is for. Especially with other AEDs.
Lyrica is a calcium channel modulator of GABA and similar to Neurontin is a compound similar in structure to GABA which can cross the blood-brain barrier unlike GABA itself.
It was unclear of what schedule it was going to be, IV or V, or none, but it was classified as V because of a rather small chance of dependence. V in some states (not medications through FDA/DEA) is also a classification of ask-the-pharmacist medication, although that has diminished because of abuse (i.e. codeine with APAP.)
poster:yxibow
thread:722714
URL: http://www.dr-bob.org/babble/20070113/msgs/722777.html