Posted by yxibow on January 6, 2007, at 13:25:22
In reply to Re: Why rozerem instead of melatonin?, posted by Cecilia on January 6, 2007, at 2:28:47
> When I tried melatonin it didn't help me sleep, and when I finally did I had nightmares. I don't know if Rozerem would be worth trying. If it were over the counter I would (I don't know why it's not, if it's basically modified melatonin), but not sure it's worse the stress of asking my doctor, when it probably would have the same effect as melatonin. Cecilia
Yes -- it was my experience of nightmares at the typical highest dose of melatonin you see wherever you shop for alternative (well one can argue melatonin and a few substances are more in the mainstream) substances -- 5mg. I woke up in the middle of a stage REM sleep and so I had hypnagogic hallucinations and felt well... kinda psychotic.
Not so with the Rozerem + remaining Ambien + my usual Seroquel which has always been there -- so there is definately something different about Rozerem and the whole combination of above (not suggesting one start on it, I just need the Seroquel and the Ambien is a crossover) that has allowed me to well, not wake up rested as a baby -- I'm sure I have some minor sleep apnea or something, but more sleep than before.
I agree that melatonin isn't a really novel substance to be patented, but you're not getting melatonin. You're getting an agent that specifically targets the same receptors that melatonin does (MT1 and MT2, partial MT3), which is not the same.
If you rotate the chemical structure of Rozerem and compare it to melatonin there are some similarities but they are not the same thing, just because they happen to both be organic compounds with nitrogen in them as well. Additionally, it is likely to be a more chemically pure substance than melatonin itself.-- tidings
poster:yxibow
thread:717885
URL: http://www.dr-bob.org/babble/20070101/msgs/719854.html