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Re: SSRI's and the heart }} madeline

Posted by sdb on January 6, 2007, at 3:01:53

In reply to Re: SSRI's and the heart » linkadge, posted by madeline on December 31, 2006, at 20:22:53

serotonin is both, a vasoconstrictor or vasodilator. These properties are related to the condition of blood vessels or is dosage dependent.

kind regards

sdb

> Yeah, I got that concern.
>
> I'm just not that worried about it.
>
> There may just not be that big of an effect in the periphery at the changes in concentration induced by the SSRI's.
>
> Serotonin is also a vasoconstrictor in the periphery. It also may play a role in platelet aggregation and clotting.
>
> We haven't seen changes in blood pressure, bleeding times or much along those lines in people on SSRI therapy.
>
> I think it is a dilution issue.
>
> Serotonin is concentrated at certain places in the brain. I think it is most likely diluted out in the periphery so a change in concentration (unless it is a big one - overdose range) probably won't matter that much.
>
> If there are effects, they are very mild and subclinical.
>
>


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