Posted by SLS on January 4, 2007, at 16:17:12
In reply to Triple Re-uptake inhibitors- why so excited?, posted by Jimmyboy on January 4, 2007, at 13:42:08
> I keep reading that these are going to be the big deal in the future,
I don't know about them being such a big deal, but they will offer an interesting alternative to experiment with.
> but aren't combo's that are already give the same effect.
No. There are no potent dopamine reuptake inhibitors currently available.
> Like combining an SSRI + Bupropion - seems like you hit all 3 there - S NE and DA.
Bupropion is a weak reuptake inhibitor at best. With the exception of Sheldon Preskorn, MD, I don't know of many psychopharmacologists willing to attribute the clinical therapeutic effects of bupropion to reuptake inhibition. I haven't kept up with it, but I think the thought on bupropion is that it ultimately produces an increase in noradrenergic neurotransmission through some yet to be determined set of mechanisms.
> Don't MAOI's do that too? Effect all 3 that is..
The key probably lies in the details of what, where, and how.
> Just wondering if there is something I'm missing here
I'm sure there is something we are all missing, including the neuroscientists. That's why I think we should keep an open mind and remain at least moderately optimistic. I find that cynicism bears very little edible fruit. (Not directed at you) Of course, constructive criticism is an entirely different tree to cultivate, especially when positive actions are taken in an attempt to improve a situation.
I guess I would like to see something radically different from reuptake inhibitors prove themselves effective and come to market quickly. Because of my history of responding only briefly to the reuptake inhibitors, I can't help but to assume that I need a drug with mechanisms of action that are very much different. But I'll try the triple-reuptake-inhibitors when they come out and remain hopeful that I will respond to them. It will be interesting to see what happens.
As I usually state, I think it is in our best interest to have more tools to work with, not less. Each tool does not have to be a miracle drug for all. It just needs to be a miracle drug for some.
- Scott
poster:SLS
thread:719292
URL: http://www.dr-bob.org/babble/20070101/msgs/719354.html