Posted by Quintal on January 4, 2007, at 9:46:26
In reply to Re: Are MAOIs worth it?, posted by djmmm on January 4, 2007, at 9:10:52
>A lot of the physical effects of what you may attribute to an amphetamine metabolite, may simply be the result of a spike in blood pressure, or the catecholamine enhancing effects of Parnate itself.
Parnate certainly did increase my heart rate after each dose.
>Im guessing, the amount of Amphetamine/Methamphetamine derived as a metabolite, would have to be VERY high to elicit a "meth-like" response (thus the reported presense of amphetamine metabolites in overdose)
Even small amounts of methamphetamine/phenethylamine produced as metabolites could elicit a powerful response when MAO inhibition is high (as it is likely to be in people taking very high doses of Parnate) due to the synergistic sympathomimetic effect. I'm not aware of any studies giving precise data on the amounts of these metabolites but I will have a look.
This has been discussed at length on PB but I don't recall a definite conclusion. Maybe some of the older members will be able to add some insight? Parnate certainly feels like a powerful stimulant at high doses for many people whatever the underlying pharmacology may be.
Q
poster:Quintal
thread:718619
URL: http://www.dr-bob.org/babble/20070101/msgs/719234.html