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Re: memantine - phillipa

Posted by rovers95 on December 28, 2006, at 3:53:43

In reply to Re: ocd out of control, will ultram or a benzo hel » rovers95, posted by Phillipa on December 27, 2006, at 17:27:33

> Is that available in the US? Love Phillipa

Yeah it is marketed as namenda, its quite expensive but not stupidly so - and if your pdoc wont approve it you could jus trial it online as it has a low s/e profile and is neuroprotective anyway.

Basically, it is an NMDA antagonist and blocks the actions of Glutamate (the excitory neurotransmitter) allowing GABA to work more effectively. Unfortunately its binding affinity isn't as strong as ketamine so it doesnt increase dopamine or downregulate the HPA axis.

I could therefore see why it failed the trials for depression (although many pdocs have success with it - and it shows antidepresiive properties in the rat!) but am sure it would be good for anxiety and some bi-polar disorders.

There is increasing evidence that some types of OCD, like some types of other affective disorders seems to be influenced by glutamate excess.........and a lot of med research seems to be heading this way!! If you can afford and your pdoc would allow i would give riluzole a blast as its going great guns in the trials, and i would expect more soon.

Have u tried l-theanine before???? Did it do anything for you? this could be a minor indicator!!

good luck!!

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URL: http://www.dr-bob.org/babble/20061224/msgs/716865.html