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Re: pindolol, does it increase the risk of diabeti » linkadge

Posted by SLS on December 24, 2006, at 6:27:37

In reply to Re: pindolol, does it increase the risk of diabeti, posted by linkadge on December 23, 2006, at 15:29:58

> I've read followup studies saying that pindolol does not enhance serotonin release and does not poses significant activity on 5-ht1a autoreceptors.
>
> These study authors theorized that augmentation must have been through an alternative mechanism.
>
> http://jpet.aspetjournals.org/cgi/content/full/291/1/229


Interesting.

What if pindolol were selective for postsynaptic receptors instead of somatodendritic autoreceptors? It might reduce the accomodation produced by fluoxetine during the first few weeks of treatment, apparantly accelerating the antidepressant response. However, it would not actually act to increase the ultimate response rate.

Just a way-out-there thought.


- Scott

 

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URL: http://www.dr-bob.org/babble/20061224/msgs/716086.html