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Re: Imipramine for anxiety? Anyone tried? » UgottaHaveHope

Posted by yxibow on December 20, 2006, at 19:13:17

In reply to Imipramine for anxiety? Anyone tried?, posted by UgottaHaveHope on December 19, 2006, at 23:03:26

> Thats what Im thinking about asking my pdoc to try for anxiety. Have you tried? What was your response?

Imipramine was the first TCA in the 50s (Tofranil); being the first it probably is less refined and has more side effects than later TCAs, but TCAs do carry certain burdens. Notably, anticholinergic activity, sedation, some cause sweating, and possible weight gain. Now this isn't to knock them -- even while SSRIs were already and still already available, Anafranil has been used for hard OCD cases. So clomipramine has some use in anxiety disorders still, as long as you can tolerate its side effects.


Getting used to sedation is probably one of them, I'm not sure, I haven't taken it before. I know doxepin is extremely sedating and is used for sleep but the sheer knockout quality for doxepin-naive people like myself turned me away from it. I do imagine that goes away, somewhat, over time but its probably the case that TCAs are taken more at night.

Maybe someone can jump in here about that issue.

 

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URL: http://www.dr-bob.org/babble/20061217/msgs/715290.html