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Re: RILUZOLE - generics, whens it gona get cheaper

Posted by rovers95 on December 5, 2006, at 16:19:40

In reply to Re: RILUZOLE - generics, whens it gona get cheaper???? » rovers95, posted by Quintal on December 5, 2006, at 8:55:34

> That's very interesting Mark. Where did you find out about its uses in psychiatry? Do you have any links?
>
> Q

Yeah, i saved the links on an email to show my pdoc!! To say the links are encouraging is an understatement..........a lot of the people experienced complete remmision of their symptoms!!!

http://ajp.psychiatryonline.org/cgi/content/full/161/11/2132

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14702270&dopt=Abstract

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15993857&dopt=Abstract

http://ajp.psychiatryonline.org/cgi/content/abstract/162/12/2379

It appears to be an nmda glutamate antagonist but with stronger binding i.e more like ketamine than memantine, it therefore increases dopamine............it also lowers cortisol (HPA axis) and inhibits voltage sensitive sodium channels and protects against excess Ca+ influx!!

slight problem though.........it is ridiculously expensive, and the drug company wants it to stay that way. They were even reluctant to give out the drug for the trials!!!!!!!!

However, it did not work for SLS from the archives
on here!!

But if you look on google in november this year another company seemed to be appealing (so far succesfully) to market their generic version of the drug!!!

mark

 

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