Posted by Quintal on December 1, 2006, at 9:54:14
In reply to Re: Racing thoughts, fear of bullying, etc. what m, posted by notfred on November 30, 2006, at 23:46:40
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7991261&dopt=Abstract
--------------------------------------------------
Vasoconstrictive effects of cocaine and lidocaine with epinephrine in the hamster cheek pouch model.Raster JF, Chow JM.
Department of Otolaryngology-Head and Neck Surgery, Loyola University Medical Center, Maywood, IL 60153.
Otolaryngologists frequently use cocaine and lidocaine with epinephrine for their anesthetic and vasoconstrictive effects. However, no studies have visually compared the vasoconstrictive effects of cocaine to lidocaine with epinephrine. This study used the everted hamster cheek pouch model to assess the vasoconstrictive effects of cocaine and lidocaine with epinephrine by measuring the diameter changes of arterioles. Our results showed that locally injected 1% lidocaine with 1:100,000 units epinephrine caused the greatest diameter reduction in arterioles to 32% of the initial resting diameter. Topical 1% lidocaine with 1:100,000 units epinephrine caused a gradual reduction in diameter with findings equivalent to those of injected 1% lidocaine with 1:100,000 units epinephrine at 30 minutes. ***Topical 5% cocaine HCl showed a minimal response, with a reduction to only 85% of the resting arteriolar diameter.*** Topical NaCl and injected NaCl controls showed no significant arteriolar reduction. Vasoconstrictive differences between the preparations were statistically significant (p < 0.05). ***Five percent cocaine is a much weaker vasoconstrictor than locally injected 1% lidocaine with 1:100,000 units epinephrine.***
PMID: 7991261 [PubMed - indexed for MEDLINE]
-------------------------------------------------->It is a vasoconstrictor all by itself, and quite a powerful one. Illicit intranasal use has this limiting factor. The vasoconstrictor effects of cocaine itself or with an added agent are to control bleeding, not to limit the "high" from it.
Otherwise no one would ever "snort" coke.Well you are saying on one hand that cocaine is a powerful vasoconstrictor, enough so to limit absorption when taken intransally, yet I know enough cocaine can still be absorbed via this route to render the cocaine abuser dangerously intoxicated.
I read, I think in the book "Intoxication" that where cocaine is used as a local anesthetic epinephrine must also be used as a vasoconstrictor to limit systemic toxic effects (for 'toxic' read 'euphoric'). Ostensibly this use is promoted as being necessary to reduce bleeding as cocaine is too weak a vasoconstrictor to do this reliably when used alone. I haven't checked to see if this is actually used in clinical practice, but the book is an excellent source of information on all things pharmacological.
Do you know for sure the plastic surgeon did not add epinephrine to the cocaine mix?
I went to school with a pair of identical twins who were dyspraxic. I think I can understand why mood disorders are common in people who have this condition.
Q
poster:Quintal
thread:708227
URL: http://www.dr-bob.org/babble/20061129/msgs/709300.html