Posted by ed_uk on October 27, 2006, at 14:39:46
In reply to Re: Phenobarbital for Anxiety » ed_uk, posted by yxibow on October 27, 2006, at 3:16:21
>It is not a second line agent typically either
No, it isn't, but that doesn't mean that it's pointless.
>But they both act on GABA
So do a lot of the other anticonvulsants, but their effects are not the same. For a start, phenobarbital and benzodiazepines bind to different receptors in the brain. Phenobarbital is not simply a 'less safe version of a benzo', it is a drug with a different mechanism of action. You cannot predict the efficacy of pheno based on whether or not a benzo was effective. The opposite is also true.
>However, the LD50 is still significantly more than clonazepam or diazepam
A large number of drugs are potentially dangerous in overdose. This does not make them pointless however. Phenobarbital still has a role in the treatment of epilepsy when other drugs have not worked or have caused intolerable side effects.
Interesting. We don't have any pheno combinations in the UK. Pheno is only available on its own, as 15mg, 30mg and 60mg tablets, and as an injection.