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Re: Phenobarbital for Anxiety

Posted by ed_uk on October 27, 2006, at 14:39:46

In reply to Re: Phenobarbital for Anxiety ed_uk, posted by yxibow on October 27, 2006, at 3:16:21

>It is not a second line agent typically either

No, it isn't, but that doesn't mean that it's pointless.

>But they both act on GABA

So do a lot of the other anticonvulsants, but their effects are not the same. For a start, phenobarbital and benzodiazepines bind to different receptors in the brain. Phenobarbital is not simply a 'less safe version of a benzo', it is a drug with a different mechanism of action. You cannot predict the efficacy of pheno based on whether or not a benzo was effective. The opposite is also true.

>However, the LD50 is still significantly more than clonazepam or diazepam

A large number of drugs are potentially dangerous in overdose. This does not make them pointless however. Phenobarbital still has a role in the treatment of epilepsy when other drugs have not worked or have caused intolerable side effects.

>Donnatal

Interesting. We don't have any pheno combinations in the UK. Pheno is only available on its own, as 15mg, 30mg and 60mg tablets, and as an injection.

Ed


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poster:ed_uk thread:697393
URL: http://www.dr-bob.org/babble/20061020/msgs/698211.html