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Re: Lyrica left me feeling worse.

Posted by linkadge on October 26, 2006, at 17:01:06

In reply to Re: Lyrica left me feeling worse. » SLS, posted by corafree on October 26, 2006, at 14:11:27

SLS reacts well to NRI's (?). Isn't there a intricate relationship between noradrenaline and glutamatergic function?

Some studies linked positive response to TCA's with a dramatically increased affinitity of zinc to hippocampal neurons. I found zinc to be a better antidepressant than magnesium. Both are NMDA antagonists, but magnesium decreases BDNF while zinc upregulates it. Zinc also increases BCL-2 like lithium. BCL-2 increase supposedly has antidepressant effect. Valproate also increases BCL-2, but not other mood stabilizers.

BCL-2 transgenic mice (with dramatically increased BCL-2), seem to have low anxiety. BCL-2 may be a target for anxiety disorders. The ratio of certain members of the BCL-2 antiapoptotic/apoptotic family has a big influence on apoptosis and anxonal regeneration.

Linkadge


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poster:linkadge thread:696596
URL: http://www.dr-bob.org/babble/20061020/msgs/697987.html