Posted by ed_uk on October 24, 2006, at 15:51:19
In reply to Re: Dexamyl for the menopause........ » ed_uk, posted by Ame-Sans-Vie on October 23, 2006, at 7:53:34
Hi M
>Wow... never thought I'd come across those.
Pretty cool huh?
>What exactly does benactyzine even *do*??
Hmmm well, I know it's an anticholinergic.
The chemical structure looks a bit like diphenhydramine. I wouldn't be surprised if it's a sedative antihistamine as well as an anticholinergic. Its strong central anticholinergic effects would explain the hallucinations which have been reported at high doses.
Aviat Space Environ Med. 1982 Aug;53(8):759-65.
Effects of an anticholinergic drug, benactyzine hyrochloride, on vision and vision performance.
Brown B, Haegerstrom-Portnoy G, Adams AJ, Jones RT, Jampolsky A.
Benactyzine is an anticholinergic agent which has been used in past years in psychiatry, but is little used today. It has central and peripheral anticholinergic effects, and when administered intramuscularly, it has a rapid onset of action. This may make it useful as an antidote for organophosphate poisoning, in spite of side-effects such as deficits of short term memory, concentration, and attention. As an anticholinergic drug it could also be expected to produce vision changes by its action on the intraocular musculature controlling the pupil and lens accommodation. We tested the drug on six volunteer subjects to establish the visual side-effects of intramuscular administration. We found that it reduced static and dynamic visual acuity, increased pupil size, reduced amplitude of accommodation and contrast sensitivity, while having little or no effect on glare recovery, color vision, intraocular pressure, stereoacuity, oculomotor tracking, and distance heterophoria. Benactyzine produced reductions in visual performance for up to 3 h and had the greatest effects on functions which have significant cognitive components. The present results suggest that the drug is unsuitable for treatment for oganophosphate poisoning when continuous performance is required, although a definitive test of ths suggestion would require that performance should be tested when benactyzine and the organophosphate of interest were combined.
Take care
Ed
poster:ed_uk
thread:696474
URL: http://www.dr-bob.org/babble/20061020/msgs/697382.html