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New study:Diabetes risk same with Zyprexa and Sero

Posted by ed_uk on October 20, 2006, at 13:44:18

In reply to Re: seroquel... » Phillipa, posted by yxibow on October 20, 2006, at 3:13:46

20 October 2006

Am J Epidemiol 2006; 164:672-681

Diabetes risk associated with use of atypical antipsychotics

An observational study has examined the risk of developing diabetes in a cohort from a national sample of US Veterans Health Administration patients with schizophrenia (and no preexisting diabetes) who were using selected antipsychotic agents. The study involved 15,767 patients who started olanzapine (Zyprexa), risperidone (Risperdal), quetiapine (Seroquel), or haloperidol (Haldol - the control group) in 1999–2001, after at least 3 months with no antipsychotic prescriptions. They were followed for just over 1 year. The study found that compared with the control group, diabetes risk was increased equally with new use of olanzapine (hazard ratio 1.64, 95% CI; 1.22, 2.19), risperidone (1.60, 1.19 to 2.14), or quetiapine (1.67, 1.01 to 2.76). In addition, diabetes risks were higher in patients aged under 50 years.

The study concluded “Assuming that the observed associations are causal, approximately one third of new cases of diabetes may be attributed to use of olanzapine, risperidone, and quetiapine in patients taking these medications. Prescribers should be mindful of diabetes risks when treating patients with schizophrenia.”




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