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Re: seroquel... Phillipa

Posted by yxibow on October 20, 2006, at 3:13:46

In reply to Re: seroquel... ed_uk, posted by Phillipa on October 19, 2006, at 18:21:33

> Ed how can it work for depression. It proves my theory that high anxiety leads to depression. It's a scam to get people off benzos. What about the diabetes lawsuit on zyprexa? Love PJ O


Its not a scam -- atypicals work on the high 5HT to D2 ratio.


Benzodiazepines don't really help depression, they actually can cause depression in those really prone to it, but more CNS depression than full depression. They're excellent and generally safe purely as directed for anxiety disorders.


Though I have mentioned it before that at least at this point in time I can't take Zyprexa because it causes (only in my experience) pseudoparkinsonism, nonetheless, my secondary depression broke in less than a week.


Besides Lithium, antipsychotics are the fastest methods to prevent suicide and antipsychotics are the fastest methods to halt certain forms of depression.


At a certain dosal range, Remeron mimics an atypical antipsychotic without the dopamine angle.


Atypicals form a blockade on serotonin receptors, a different form of antidepressant (as in Remeron, besides the alpha receptor which is activated, various 5HT receptors are blockaded in a certain quantity).


This doesn't mean that they are to be taken lightly (literally), as you mention the pitfalls of Zyprexa. A certain number of people will develop diabetes on Zyprexa if left too long without proper doctor evaluation. Continued tests (I continue to get tests frequently for Seroquel) are necessary and should be done and a diet/weight program should be instituted should there be issues and a possible change to a different AP.


As for lawsuits, well, this is a litigious society and while there are certain things that merit lawsuits, like Thalidomide and the like, it has been known for a while now about the lipid profile changes of some antipsychotics, unfortunately, some of them are those with the lowest risk of TD. I am not aware of the specifics of the lawsuit; this may have been filed before extensive Phase IV data had been collected.


There is a certain concept of informed consent, and I have been informed of possible things that could happen with Seroquel or any drug I take by my doctor (not that I haven't already probably researched it in PIs or the PDR being one of those patients who feels the need to self-educate and generally because I have a disorder that doesn't really fit into a known quantity per se.)

- tidings

Jay

 

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