Psycho-Babble Medication | about biological treatments | Framed
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Re: seroquel... med_empowered

Posted by ed_uk on October 19, 2006, at 16:18:59

In reply to seroquel..., posted by med_empowered on October 19, 2006, at 16:01:25

Hi Med,

CATIE found that Seroquel had the highest drop-out rate among users, with 82 percent of patients discontinuing treatment within 18 months.

That compared to 64 percent for patients on Zyprexa, 74 percent for Risperdal, 79 percent for Geodon and 75 percent for the potent typical neuroleptic perphenazine.

>great for...anxiety, bipolar, agitation, etc. etc

From the AstraZeneca website........

'Seroquel SR will importantly extend the life cycle of Seroquel because the patent will be protected until 2017'

And of course......

'In addition to the Schizophrenia indication, Im delighted to tell you we are planning a clinical program for Seroquel SR in Bipolar Disorder. This will enable submissions for Bipolar Depression and Mania globally in 2008 with this exciting, new formulation. Again, our aim is for the SR formulation to offer differentiating benefits compared to the IR formulation in Bipolar Disorder by providing a simple titration scheme that will enable a patient to reach a once-daily target dose earlier. The clinical trial program for SR will also include a broader patient population than the current bipolar data on IR with the inclusion of mixed and rapid cyclers'


'A new clinical program is underway to study Seroquel SR in Major Depressive Disorder and Generalized Anxiety Disorder which will deliver indications from 2009'

It made me laugh how they say it will 'deliver indications'

And as we already have noticed......

'The depression market is currently worth 19 billion USD, while currently relatively flat our view is that this market will return to growth driven predominantly by increasing usage of atypicals'

>I seem to recall reading that seroquel has a tendency to induce dopamine supersensitivity (more so than other atypicals, I guess). I forget the mechanism..something about loose binding mixed with a short half-life

I've read something similar. I think it was saying that people tended to relapse particularly rapidly when Seroquel was discontinued and that tolerance sometimes developed to its antipsychotic efficacy.





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