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ironic, memantine may be helpful for OCDw/Hoarding

Posted by iforgotmypassword on October 18, 2006, at 11:37:20

In reply to Re: memantine-what does everyone think???, posted by rovers95 on October 14, 2006, at 23:23:20

this is important as very little is. (low functioning anterior cingulate is seen in hoarding)

this is only a maybe, as i am extrapolating this.

ketamine increases blood flow to the anterior cingulate.

article on pubmed: "[Glutaminergic hypothesis of schizophrenia: clinical research studies with ketamine]"

now, strangely even though in this case it is positive in the article (lamotrigine cutting out ketamine induced pos. and neg. symptoms), there may be chance lamotrigine cancels out NDMA benefit.

or maybe they are a good match, with lamotrigine attenuating bad effects. who knows.

it is also pretty messy with its binding affinities according to rx list, some of these receptors that even cause squirelly effects even with slight interaction:

"Memantine showed low to negligible affinity for GABA, benzodiazepine, dopamine, adrenergic, histamine and glycine receptors and for voltage-dependent Ca2+, Na+ or K+ channels. Memantine also showed antagonistic effects at the 5HT3 receptor with a potency similar to that for the NMDA receptor and blocked nicotinic acetylcholine receptors with one-sixth to one-tenth the potency."




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