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Re: memantine-what does everyone think???

Posted by SLS on October 14, 2006, at 6:25:47

In reply to memantine-what does everyone think???, posted by rovers95 on October 13, 2006, at 20:19:49

> hi, fed up off suffering from my long term anxiety w/depression-im considering using memantine to augment lamictal (which i start next week), what do people think and what are peoples experience with memantine.....i.e. is it worth the cost!!

I responded to memantine intermittently over the course of two weeks at a dosage of 20mg. I was taking Lamictal at the same time. Another person posting on PB experienced a more stable, albeit inadequate response to a low dosage of approximately 5mg. I can't recommend it, but I would not want to dissuade you from trying it either.

The NIH trial showed memantine to be ineffective in treating unipolar depression. They are still studying it for bipolar depression.

- Scott


: Am J Psychiatry. 2006 Jan;163(1):153-5.

A double-blind, placebo-controlled study of memantine in the treatment of major depression.

Zarate CA Jr, Singh JB, Quiroz JA, De Jesus G, Denicoff KK, Luckenbaugh DA, Manji HK, Charney DS.

Mood and Anxiety Disorders Program, National Institute of Mental Health, Department of Human Health Services, Bethesda, MD, USA.

OBJECTIVE: This study was designed to assess possible antidepressant effects of memantine, a selective N-methyl-D-aspartate (NMDA) receptor antagonist in humans. METHOD: In a double-blind, placebo-controlled study, 32 subjects with major depression were randomly assigned to receive memantine (5-20 mg/day) (N=16) or placebo (N=16) for 8 weeks. Primary efficacy was assessed by performance on the Montgomery-Asberg Depression Rating Scale (MADRS). RESULTS: The linear mixed models for total MADRS scores showed no treatment effect. CONCLUSIONS: In an 8-week trial, the low-to-moderate-affinity NMDA antagonist memantine in doses of 5-20 mg/day was not effective in the treatment of major depressive




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