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Re: Tricyclics - Q for SLS et. al. regarding ...

Posted by SLS on October 13, 2006, at 8:05:27

In reply to Re: Tricyclics - Q for SLS et. al. regarding ... SLS, posted by Darwin on October 13, 2006, at 2:34:06

> Hi Scott,
>
> The following two sites seem to imply that amitriptyline is a somewhat weak NE alpha-2 antagonist:
>
> http://www.gpcr.org/7tm/ligand/Seeman/a2adren1.html
>
> http://www.preskorn.com/columns/9803.html (Table 2)
>
> Clearly, amitriptyline's NE alpha-2 antagonism is too weak to produce an antidepressant effect by itself but perhaps, combined with amitriptyline's many other modes of action, it may slightly elevate amitriptyline's overall antidepressant effectiveness. Then again, maybe not.


Thanks for the links.

The dissociation constant seems high enough that it might play a role. Amitriptyline was, prior to clomipramine, considered to be the most potent tricyclic antidepressant. I can understand why.


- Scott

 

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