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Re: Tricyclics - Q for SLS et. al. regarding ... SLS

Posted by Darwin on October 13, 2006, at 2:34:06

In reply to Re: Tricyclics - Q for SLS et. al. regarding ..., posted by SLS on October 12, 2006, at 16:19:54

Hi Scott,

The following two sites seem to imply that amitriptyline is a somewhat weak NE alpha-2 antagonist:

http://www.gpcr.org/7tm/ligand/Seeman/a2adren1.html

http://www.preskorn.com/columns/9803.html (Table 2)

Clearly, amitriptyline's NE alpha-2 antagonism is too weak to produce an antidepressant effect by itself but perhaps, combined with amitriptyline's many other modes of action, it may slightly elevate amitriptyline's overall antidepressant effectiveness. Then again, maybe not.

Darwin


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URL: http://www.dr-bob.org/babble/20061011/msgs/694392.html