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Re: Tricyclics - Q for SLS et. al. regarding ...

Posted by SLS on October 12, 2006, at 16:19:54

In reply to Re: Tricyclics - Q for SLS et. al. regarding ... michael, posted by Darwin on October 12, 2006, at 13:41:58

Amitriptyline does look attractive here. I guess the main thing is whether or not it is tolerated with regard to sedation. The only property listed here that I have not seen literature for is the NE alpha-2 antagonism.

> Also, amitriptyline hits most of the antidepressant mechanisms:
> * norepinephrine reuptake inhibition
> * serotonin reuptake inhibition
> * alpha-2 receptor antagonism
> * 5ht2a recepton antagonism
> * cholinergic receptor antagonism

- Scott




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