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Re: **CORTISOL** » SLS

Posted by sregan on October 5, 2006, at 16:33:30

In reply to Re: **CORTISOL**, posted by SLS on September 26, 2005, at 9:00:00

> Using either mifepristone or dexamethasone for brief, paroxsysmal, one-week courses of treatment probably acts to stress the system into changing gene expressions that control relevant receptor sensitivities, second messenger events, and secretory responses.

Scott,

When a neuro-receptor is blocked the effect is immediate. If you block NMDA then you feel less anxious. With the HPA negative feedback I get confused on what is doing what. A glucocorticoid receptor antagonist should INCREASE circulating glucorticoids because if the receptors are blocked then the monitoring mechanism thinks they are LOW and need to be increased? So it actually increases CRH->cortisol?

Shawn


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poster:sregan thread:558802
URL: http://www.dr-bob.org/babble/20061003/msgs/692144.html