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Re: buspar properties; gepirone available anywhere » iforgotmypassword

Posted by yxibow on September 27, 2006, at 9:53:10

In reply to buspar properties; gepirone available anywhere?, posted by iforgotmypassword on September 25, 2006, at 15:50:39

> (NOTE: *NOT* asking how to get an unapproved med; simply asking if it is technically-speaking available anywhere.)
>
> buspirone seems odd in its dopaminergic effects, specifically anti-dopaminergic effects. it seems to be well known as a D2 blocker. but it may also be a PRESYNAPTIC dopamine AUTOreceptor AGONIST, which is even spookier.
>
> it also may be indirectly anticholinergic. (whew!)
>
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=6123570&query_hl=26&itool=pubmed_docsum
>
> buspirone at high dose worsens parkinson's symptoms.
>
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=3026624&query_hl=26&itool=pubmed_docsum
>
> this is awkward... i want to try low doses anyway, but given how i get the extrapyramidal pseudoparkinsonian signs from SSRIs and even spontaneously (may be a lyme effect) i worry heavily.
>
> i also am a hoarder, and have severe apathy/amotivation/concentration problems so anticholinergic effects scare me that way too.
>
> gah.
>
> anyone have any NEW news on gepirone? any new signs of life?

An NDA was filed for Gepirone by Fabre Kramer, who took it from Organon, in 2006. Its possible marketed name may be Veriza / Ariza.

http://www.fabrekramer.com/products.html


As for BuSpar -- it is a failed antipsychotic used as an anxiolytic so it does have some of those properties. Only about 1/3 of the people respond for anxiolytic relief on it.


On the other hand it has been used, albeit with pseudoparkinsonism, in experimental treatments against TD in astronomical amounts of it.


At the regular doses the main thing I felt was some faintness / lightheadedness.

-- Jay

 

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poster:yxibow thread:689124
URL: http://www.dr-bob.org/babble/20060927/msgs/689571.html