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Glutamatergic neurotransmission and mood disorders

Posted by SLS on September 12, 2006, at 13:07:32

Lithium and valproate (Depakote) reduce glutamate receptors in hippocampus. These drugs are predominantly anti-manic.

Lamotrigine (Lamictal) and riluzole (Rilutek) increase glutamate receptors in hippocampus. These drugs are predominantly anti-depressant. Imipramine, an antidepressant, produces similar results.

It seems that the more we know, the less we understand. Of course, we are getting closer and closer to the point where all of this data will fit into their appropriate places in the puzzle, and all will be understood. Well, maybe not all. What would the brain be without mystery?


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The Anticonvulsants Lamotrigine, Riluzole, and Valproate Differentially Regulate AMPA Receptor Membrane Localization: Relationship to Clinical Effects in Mood Disorders

http://www.nature.com/npp/journal/vaop/ncurrent/abs/1301178a.html

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So much for Prozac and serotonin-deficiency theory.


- Scott

 

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