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Re: High dose Namenda

Posted by SLS on September 9, 2006, at 14:40:08

In reply to High dose Namenda, posted by BIGDaddyachmed69 on September 9, 2006, at 10:58:31

40mg of Namenda made me feel sort of drunk and high. I didn't like it, so I went back down to 20mg. I felt somewhat better for awhile at 20mg during the second and third weeks, but I ultimately gained no improvement in depression beyond this.

- Scott


Am J Psychiatry. 2006 Jan;163(1):153-5.

A double-blind, placebo-controlled study of memantine in the treatment of major depression.

Zarate CA Jr, Singh JB, Quiroz JA, De Jesus G, Denicoff KK, Luckenbaugh DA, Manji HK, Charney DS.

Mood and Anxiety Disorders Program, National Institute of Mental Health, Department of Human Health Services, Bethesda, MD, USA.

OBJECTIVE: This study was designed to assess possible antidepressant effects of memantine, a selective N-methyl-D-aspartate (NMDA) receptor antagonist in humans. METHOD: In a double-blind, placebo-controlled study, 32 subjects with major depression were randomly assigned to receive memantine (5-20 mg/day) (N=16) or placebo (N=16) for 8 weeks. Primary efficacy was assessed by performance on the Montgomery-Asberg Depression Rating Scale (MADRS). RESULTS: The linear mixed models for total MADRS scores showed no treatment effect. CONCLUSIONS: In an 8-week trial, the low-to-moderate-affinity NMDA antagonist memantine in doses of 5-20 mg/day was not effective in the treatment of major depressive disorder.

Publication Types:

* Randomized Controlled Trial




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