Posted by Squiggles on September 2, 2006, at 9:13:27
In reply to Re: Clonazepam dosing » Squiggles, posted by SLS on September 2, 2006, at 9:05:38
> I experienced a manic reaction to antidepressant medication while taking Ativan 2mg concurrently for sleep. The addition of lithium did not help much. The addition of Klonopin did.
It is one thing to add lithium to a manic
reaction (what was the dose? 200mg, 300mg, 600mg?); there is threshold for pharmacological
action in all drugs; If Klonopin helped, on top
of the Ativan dose, that may have been enough.
Furthermore, a "manic reaction to an antidepressant" may have infact been a transient
agitation, and not part of the bipolar spectrum
kept under wraps for years with a full dose of
lithium and 1.50mg clonazepam (along with Synthroid).
>
> Klonopin is unique among benzodiazepines in that it exerts serotonergic effects (as does lithium). The exact mechanisms remain obscure.I think i came across that in the PubMed series -
again how much and for what condition would this
be significant and is it comparable to a full
lithium dose 900-1200 for bipolar? Just about anything you eat contains some serotonin.Squiggles
>
>
> - Scott
poster:Squiggles
thread:679936
URL: http://www.dr-bob.org/babble/20060901/msgs/682245.html