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Re: Thoughts on BUPRENORPHINE.

Posted by free_electron on August 26, 2006, at 11:53:32

In reply to Thoughts on BUPRENORPHINE., posted by JahL on August 23, 2006, at 1:27:14

Hi Jah,

> 1/ Does anyone have an idea of what the optimal dose *might* be for a depressed individual who is relatively opioid-naive? The literature talks of seemingly heroic doses of up to 16mg, but I imagine this would be for opioid-tolerant persons (ie poor heroin addicts). In the past I have taken Methadone and peak effects were experienced at a mere 5ml (1mg:1ml), and sustained for many years.

If you're going down the bupe road I suggest you use whatever minimum dose works for you. 0.2 mg sounds reasonable for a non-habitual opiate/opioid user.


> 2/ How often should one take it? The literature describes a mean half-life of 37 hours and so I imagine (correctly??) once daily dosing would be sufficient?

Technically 1/day is enough

> 3/ Are there any tolerance issues related to Buprenorphine administration?

Yes. So try to stick to whatever mimimum dosage works for you. Getting off long-term buprenorphine use is in my experience far more painful than getting off heroin.

Good luck

Peter


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