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Re: Valproate + Lamictal for BP2-doses

Posted by SLS on July 28, 2006, at 9:51:37

In reply to Valproate + Lamictal for BP2-doses, posted by C5 on July 28, 2006, at 9:37:27

> is there anyone there who can advise(from experience etc.)on the dose range for Valproate(long)if to be administered together with the (optimal dose range)for Lamictal due to the fact that these 2 are synergistically affecting each other?

Generally speaking, you go with the dosage of Valproate that you think is best according to your doctor's experience and cut the dosage of Lamictal in half. If the target dosages of each drug separately would be Depakote 1500mg and Lamictal 200mg, the combination would result in dosages of:

Depakote 1500mg + Lamictal 100mg

If you are taking Depakote at the same time, you would need to start the Lamictal at a low dosage and raise it gradually to avoid provoking a dangerous rash reaction:

12.5mg x 2 weeks
25mg x 2 weeks
50mg x 1 week
100mg

* For the first 2 weeks, the current package insert says to take 25mg every other day. The original package insert said to take 12.5 each day. I don't know why the change was made.


- Scott

 

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