Posted by Kon on July 21, 2006, at 18:59:59
In reply to Re: couldn't have said it better myself, posted by SLS on July 19, 2006, at 5:57:36
>The results of this study suggest that antidepressant-placebo differences may be larger among those depressed outpatients with higher pre-treatment HAM-D scores compared to those depressed outpatients with lower pre-treatment scores.
The problem is that other studies/reviews suggest otherwise. For instance Kirsch et al write:
"In response to the point about severity of depression, we reiterate that the NICE data did not demonstrate a gradient. The Ansgt et al meta-analysis cited also did not show convincing evidence of a gradient and other research we cited suggests that antidepressants are not very effective in more severe conditions. We did acknowledge that some research had shown such a gradient and we thank those authors who drew our attention to the fact that the same group have reproduced this finding. We still feel the evidence so far is inconclusive. Professor Taylor (rapid responses) cites further evidence against a relationship of efficacy and severity for tricyclic antidepressants as well as SSRIs.
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