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Re: 1/2 an emsam patch - both types of mao inhibit » crabwalk

Posted by Donna Louise on July 19, 2006, at 16:13:52

In reply to Re: 1/2 an emsam patch - both types of mao inhibit, posted by crabwalk on July 19, 2006, at 11:46:21

> It might be a moot question anyway because of individual variation, for instance some people are sensitive to less than 5mg of prozac. But my thinking was a) oral selegiline goes through much more metabolism before reaching the cortex than does transdermal, and b) oral doses are taken once or twice a day while transdermal is essentially a drip-feed or a very stable controlled-release, and this surely affects the stability of plasma and cortical levels of the drug. I have no idea if either/which of these makes the substantial difference, but it could work out that a lot of oral selegiline=not much transdermal.

I think it means that their is more selegiline transdermally and less metabolites than orally. By bypassing the liver, not as much of the originally drug is broken down into its amphetamine metablolites and more parent drug is available directly to the bloodstream and therefore the brain.

donna


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