Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

Re: Drug interaction tool online? » Phillipa

Posted by Squiggles on July 18, 2006, at 12:02:11

In reply to Re: Desperate here..opinions on Chloral Hydrate Please » Crazy Horse, posted by Phillipa on July 18, 2006, at 11:31:40

I read in Healy's "The Creation of Psychopharmacology", p. 43, the following:

"Within mental hospitals, the pressing need was
for sedation.....Liebig and Wohler synthesized
chloral in 1832. In 1869, Otto Liebrich discovered
that chloral had more reliable sedative properties
than any other drug at that time. Liebrich's discovery led rapidly to chloral's widespread use for sedation [14]."
----------

I think it was also used in dentistry in the
early days. However, the problem with
this sedative was what we would now say it has a
narrow therapeutic index. A little too much
and the respiratory failure would lead to death.
It is a dangerous drug:

1: Vet Hum Toxicol. 1979;21 Suppl:53-6. Related Articles, Links

Chloral hydrate poisoning: its mechanism and therapy.

Gerretsen M, de Groot G, van Heijst AN, Maes RA.

Chloral hydrate is a dangerous hypnotic drug to prescribe. Lethal dose can be a small as 4 gm. Nowadays the effects on the circulatory system are most dangerous. Which metabolite is responsible remains to be investigated. Haemoperfusion seems to be best method of lowering plasma levels of the metabolites, although the clearance of trichloroacetic acid is considered lower than of trichloroethanol.

Publication Types:

* Case Reports


PMID: 505984 [PubMed - indexed for MEDLINE]

Squiggles


Share
Tweet  

Thread

 

Post a new follow-up

Your message only Include above post


Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.

 

Start a new thread

 
Google
dr-bob.org www
Search options and examples
[amazon] for
in

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:Squiggles thread:667977
URL: http://www.dr-bob.org/babble/20060717/msgs/668000.html