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Re: To Those Who Switched From Celexa to Lexapro..

Posted by SLS on July 13, 2006, at 11:34:57

In reply to To Those Who Switched From Celexa to Lexapro..,,,,, posted by qbsbrown on July 13, 2006, at 11:04:34

> I am switching from 60mgs. Seems to be much confusion as to whether i go to 20mgs or 30mgs lexapro, due to the lack of knowledge of ratio between the two drugs (PDOC says 30, GP says 20).
> What were your dosages, and what did you cross over to?
> How did you feel? Any change in time you took the med (morning-night).
> Improvement in sexual functioning/drive?
> Any other details, I'd greatly to hear personal experiences.
> Regards,
> Brian

Hi Brian.

Interesting stuff on the Lexapro/Celexa dosage ratios. Lexapro is more than twice as potent as Celexa. It is probably 20/60.

Celexa contains a combination of the two enantiomer forms of the drug molecule: R- and S-

Lexapro contains a purified preparation containing only the S- version. This is the molecule that does all the therapeutic work.

It turns out that the inactive R- enantiomer actually works against the therapeutic S- enantiomer. R- competes with S- allosterically at the serotonin transporter site and interferes with the inhibition process.

Doctors have been going higher and higher with Lexapro recently. I'm really not sure where the "sweet spot" is anymore. I would guess that 40mg would be considered the dosage to work up to before giving up on it. Generally speaking, 20mg is demonstrably more effective than 10mg.

- Scott




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