Posted by Squiggles on July 8, 2006, at 19:58:01
In reply to Re: AUC, grapefruit }} Squiggles, posted by sdb on July 8, 2006, at 19:47:08
> There is more to tell about but bioavailability (AUC = Area under the curve) means the amount of substance that really reaches for example the receptors of brain GABA-CL channels in the case of diazepam, clonazepam.
>
> sdbThank you. Pharmacology is fascinating. I looked
at the Merck manual but that (with the exception of endocrinology and cardiac chapters) is one of the most complex; maybe because it is so mathematical.Yes, I would imagine that through the vein is the fastest, uninterrupted route to the brain of any drug, as no organ or condition of the body or other drug can interfere in its reaching the brain; unless there is low blood pressure, or some arterial disease or maybe even anemia.
Squiggles
poster:Squiggles
thread:662997
URL: http://www.dr-bob.org/babble/20060701/msgs/665231.html