Posted by hgi698 on June 22, 2006, at 19:48:30
In reply to Re: d1 and d2 receptors, posted by linkadge on June 22, 2006, at 15:25:43
I found the article that talked about it.
Dopaminergic Mechanisms in Depression and Mania
"In similar vein, antidepressant effects on withdrawal of neuroleptics are well documented, though the evidence tends to arise from case reports rather than formal studies . In a controlled trial, Del Zompo et al. treated depressed patients with a cocktail of haloperidol and chlorimipramine, and reported marked improvement, relative to a group treated with chlorimipramine alone, when the haloperidol component was withdrawn after three weeks treatment. It was assumed that the improvement resulted from the unmasking of DA receptors rendered supersensitive by chronic neuroleptic treatment . Clearly, more trials of this kind are needed, and the proposed mechanism of action requires confirmation."