Posted by Jost on May 22, 2006, at 20:45:06
In reply to Re: A great read re: MAOI's, posted by linkadge on May 21, 2006, at 22:05:26
> EMSAM might affect REM sleep in a manner more like Wellbutrin. I think the MAO-A inhibition is needed for the REM suppressant effects.
>
> I think that REM sleep tries to ballance the noradrenergic/cholinergic systems. If REM is not working properly, or is increased (such as in some depression), perhaps there is a cholinergic dominance and hence depression.
>
> The funny thing is that REM sleep supression itself increases serotonin in the hippocampus
> REM supression also decreases the beta-adrenergic and 5-ht2 systems as is seen with antidepressant treatment.
>
> Interestingly enough, rats that undergo REM deprivation also show increased sensitivity of d2 receptors, as is often seen with effective antidepressant treatment.
>
> LinkadgeThat's interesting, Linkadge. Any references for it? I'm interesting in the phenomenon of dreams.
Thanks, Jost
poster:Jost
thread:646311
URL: http://www.dr-bob.org/babble/20060520/msgs/647102.html