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Re: Did Nardil PERMAMENTLY cure my SP??

Posted by Tepiaca on May 19, 2006, at 10:09:54

In reply to Did Nardil PERMAMENTLY cure my SP??, posted by Michael Bell on May 18, 2006, at 23:59:49

Hi , I took Nardil for 2 continuos years , then when I stopped I thougth I was cured . It happened something similiar to you . Then after more time the discomfort returned . I thougth I was gonna be able to live without but I was wrong, Im on it again.

I dont wana discorageous, maybe we all are different but that was my case.

Im on Nardil again in these months

Tep


> Sorry if this seems like a shock thread title, but please bear with me for a minute and I'll explain.
>
> Before using Klonopin and/or Nardil, I suffered from severe SP. Abject terror at the thought of social situations, even among family, avoiding people and parties, constant thoughts of being judged and scrutinized by others - you name it, I had it. Twenty-odd years of this hell.
>
> Then came a long time (several years) of being on klonopin, then klonopin+nardil, and finally just nardil.
>
> My nardil script ran out more than 3wks ago and i decided not to refill it, to take a chance w/o it. I am currently on no meds at all.
>
> Where is my SP? It hasn;t returned yet, neither the overwhelming physical symptoms nor the extreme paranoia. The ruminating thoughts are still there, but they were something that nardil and klonopin didn't eliminate anyway, so I'm not surprised.
>
> So I've started thinking, is it possible that the nardil has permanently curtailed, if not cured, my SP? At first I thought that there was no way this is possible. But then I considered this...
>
> Apparently, learned fear can be eliminated. This is what the new discoveries surrounding Cycloserine deal with, that the partial glycine receptor agonist, combined with exposure therapy, actually eliminates the process of fear being imprinted on your mind, so to speak. So there seems to be some physiological process that causes some people to "learn" fear to a much greater extent than others, and there is also a mechanism that allows them to "unlearn" it.
>
> Experiments with Cycloserine have shown that after a couple weeks of continuous Cycloserine use, the elimination of fear lasts a couple months, then slowly returns. A couple more weeks of usage, and it goes away again for about 2 months. True this is not "permanent", but there is definitely some sort of fundamental restructuring of thought processes occurring, as opposed to just masking symptoms of anxiety.
>
> Is it possible that Nardil use can also effect glycine or other receptors in a way that causes users to "unlearn" their fears on a really fundamental level? After all, why would that effect be unique to Cycloserine? Regarding combining it with exposure therapy, if Nardil decreases SP to the point where you can encounter social situatioins on a daily basis, then every time you are in a social situation isn't that a type of exposure therapy?
>
> Another thought: extended alcohol use can cause permanent changes to the GABA receptors. Is it possible that certain medications could have the same effect after they've been used for a relatively long period of time?
>
> Alot of questions and thinking out loud, sorry about that. But naturally I'm curious about the SP not returning yet.
>
> Don't get me wrong, I certainly do NOT want to ever have SP again, ever!!!
>
> But I'm curious - has anyone taken Nardil, or any drug for that matter, for a very long time, and then noticed that its effects lasted for a long time after discontinuing? Has anyone ever heard of something like this happening with Nardil or another med?
>
> I would love to hear your feedback. Thanks so much.


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poster:Tepiaca thread:645783
URL: http://www.dr-bob.org/babble/20060515/msgs/645868.html