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Re: grapefruit juice-drug interaction » Larry Hoover

Posted by blueberry on May 9, 2006, at 18:04:47

In reply to Re: grapefruit juice-drug interaction » bassman, posted by Larry Hoover on May 9, 2006, at 15:00:57

In my experience st johns wort would win hands down in a contest opposing grapefruit juice, except maybe if you drank a few gallons a day. SJW metabolism effects are very very strong, in both induction and inhibition, depending on the med it is combined with. Though we usually hear about how sjw lowers the effectiveness of many drugs by increasing their metabolism, it also raises zyprexa levels by 300%. Happened to me. It was scary. It was through a different route than 3A4.

> > In today's news, we have:
> > http://news.yahoo.com/s/nm/20060509/hl_nm/grapefruit_dc
> >
> > the new discovery that furanocoumaridins (sp?) are the guys in grapefruit juice that interfere with the metabolism of some drugs.
>
> Not to be too anal, I hope, but there are inhibitory flavonoids (naringin, naringenin) in grapefruit, as well.
>
> As always, the dose makes the poison.
>
> I wonder how it would change if one was to concurrently consume a 3A4 inducer, like St. John's wort, with an inhibitor. Which would win?
>
> Lar


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