Posted by blueberry on May 4, 2006, at 6:56:00
In reply to Feeling more depressed on Cymbalta. Suggestions??, posted by addinbc on May 3, 2006, at 13:02:01
Same thing happens with me on some meds. With either milnacipran or cymbalta or wellbutrin I get a first day good effect, followed by a fairly decent 2nd or 3rd day, followed by a much deeper depression than I had and a total lack of motivation to do anything but die. And then when I stop them, I get even more depressed for 2 to 3 days as that norepinephrine drains away. On the good side, there is usually a rebound or boomerang effect where you will actually feel pretty good maybe the 2nd or 3rd day after stopping. But it is short lived.
My theory is that the extra norepinephrine buildup just causes everything to shut down and stop firing. It takes about 2 weeks for the receptors to adjust and resume firing. In the meantime, things feel real bad. I have never been able to make it through that period. I don't know why it only happens to some of us and not everyone.
poster:blueberry
thread:639621
URL: http://www.dr-bob.org/babble/20060504/msgs/639864.html