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Anyone tried tianeptine plus ropinirole?

Posted by Tony P on May 3, 2006, at 18:20:00

Has anyone tried the combination of tianeptine (Stablon) and ropinirole (Requip)? Anyone have any information on possible adverse interactions between the two?

I have been trying tianeptine recently with moderately good results. For a couple of reasons, I haven't had more than 2 weeks consecutive on it, so it's still early days. My experience so far is that it's quite mild; I feel more positive, less depressed, withdrawn and despairing. Although this morning I felt really sad for the first time in a while -- I actually see that as a positive thing, since for me depression generally leads me to feeling really flat, so when my feelings come back it's a good sign! But it doesn't so far have the motivating kick that, say, Effexor or Wellbutrin do. I found both the latter hard to tolerate so I'm looking for middle ground.

I've wondered for a couple of months now about adding ropinirole or another dopamine agonist as an adjuvant, especially since the lamotrigine I had been taking until 6 weeks ago kind of kept my depression under control but left me blah -- no sense of well-being or positive energy. Then I saw the news about ropinirole's new use for restless leg syndrome -- I've been suffering intermittently from that, or more like whole body akathisia, especially when I take Neurontin & Seroquel at night. So there'd be two reasons for taking it, and maybe there's some underlying relationship?

I'm currently taking:

Tianeptine 12.5 mg qid
Neurontin 600 mg at bedtime
Seroquel 50 mg at bedtime (but not every day).

My pdoc says he's willing to try adding the ropinirole but asked me to do some research on possible interactions. Can anyone help?


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poster:Tony P thread:639715
URL: http://www.dr-bob.org/babble/20060429/msgs/639715.html