Posted by Meri-Tuuli on April 30, 2006, at 15:02:20
In reply to Re: Moclobemide.......help!, posted by capricorn on April 30, 2006, at 14:26:55
Thanks Capricorn! (although I might need a translation)
So basically it is saying that erm,
1) Take moc AFTER a meal (I think I read this in an abstract somewhere else too)
2) Its fine to consume *normal* amounts of food, even tyramine containing ones. Just not alot of it ie 300g of strong cheese or 100g yeast extract. So basically 150mg of tyramine is needed to raise blood pressure by 30mmHg. Which is quite alot of cheese when I think about it. And not that much of an increase in blood pressure even if I were to consume 300g cheese.
Which I guess it says in the insert anyway.
ARGHHH I can't cope with all this!!!!!!
Well anyway I'm going to avoid all cheese altogether, um, yeast extract and er all the other maoi diet stuff. That way I can be sure that at least if I do eat some accidentally then it will be fine, because it will just be a normal amount, like abit of yeast extract in soup in a cafe, or something like that.
Oh man, this is crazy for someone who has a fear of poisening herself anyway.
Well regardless I have a blood pressure cuff and I took it 120/74 which is pretty normal.
And rest assured I'm only on 150mg/day for now anyway.
Well I'm going to start tomorrow regardless of my poisening phobias. I need to put that aside and think about it logically.
> 1: Acta Psychiatr Scand Suppl. 1990;360:78-80. Related Articles, Links
> Interaction between orally administered tyramine and moclobemide.
> Zimmer R, Puech AJ, Philipp F, Korn A.
> Pharma Clinical Research, F. Hoffmann-La Roche, Basle, Switzerland.
> This article describes a standardized oral tyramine pressor test designed to give information on safety aspects in the real everyday life situation where tyramine is ingested only with food. Results showed that significantly higher doses of tyramine were required to raise standing blood pressure by at least 30 mmHg (TYR 30) when it was taken with food than when subjects fasted. The same test was then conducted in 8 healthy volunteers during treatment with moclobemide 200 mg 3 times daily and tranylcypromine 10 mg 3 times daily. With moclobemide the mean TYR 30 dose was 306 mg, and the ratio of this to baseline was 5.0. With tranylcypromine, however, the mean TYR 30 dose was only 35 mg and the TSF ratio 38.2. The potentiation by tranylcypromine was thus 7.6 times greater than that of moclobemide. When tyramine was given in the food under treatment with MAO inhibitors, the TYR 30 doses were larger than those obtained under fasting conditions, but the TSF ratios were not altered. When the tyramine was given in a protein-rich or a lipid-rich meal, the previously established TYR 30 had significantly less effect on the blood pressure. The lowest TYR 30 dose during moclobemide treatment is at least 150 mg tyramine, an amount contained in about 300 g strong cheese or 100 g of yeast extract. These quantities are unlikely to be consumed in a normal meal. The corresponding TYR 30 dose for tranylcypromine, however, is only 20 mg tyramine, which can easily be contained in a fairly normal portion of strong cheese (40 g).(ABSTRACT TRUNCATED AT 250 WORDS)