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Re: EMSAM-Day 5-Too early??

Posted by crabwalk on April 24, 2006, at 19:09:15

In reply to Re: EMSAM-Day 5-Too early??, posted by SFY on April 24, 2006, at 13:03:36

On this note, I'm getting some pretty bad anxiety from emsam on day 3. It's been sort of a rollercoaster ride so far. Very depressed and anxious the first day in a way that I'm not usually depressed. A little better yesterday, especially in the evening, and then this morning started getting my hopes up. Was feeling pretty good until maybe 10:30 and then all of a sudden I crashed and got very, very anxious, though not necessarily agitated. Been pretty anxious the rest of the day, but at least some of this is due to external factors.

I'm a pretty atypical case though, since I'm looking for something that will undo the damage to my sexual functioning that ssris did. This probably wouldn't have been my first choice just for anxiety, which is what I had to begin with.

Has anybody else hit anxiety, and does anybody know if it could wear off like it does for some with wellbutrin?

> Don't get me wrong, I'm not an Emsam doubter. (In fact, it's going to be my next step if my current meds regimen doesn't pan out.) But I don't think we should minimize the ocurrence of side effects (and interpreting statistics correctly will help us all to better understand study results).
> In the study earlier cited, 7.1% of Emsam users dropped out due to adverse effects versus 3.6% of placebo users. 7.1% is not 3.5% higher than 3.6% but nearly 100% higher since nearly twice as many people on Emsam dropped out than those on placebo.
> If we had a total sample size of 1000 in the study, then 71 Emsam users and 36 placebo users would have dropped out. Thus 35 more or 97% more Emsam users than placebo users dropped out due to adverse reactions. If it were only 3.5% more than there would have been only 1 (0.035 x 36) more person dropping out which was clearly not the case.
> Thus Emsam's side effects (or at least their severity leading to discontinue treatment) are noticeably greater than those encountered with placebo.




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