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buprenorphine doses SLS

Posted by pseudoname on April 22, 2006, at 15:43:57

In reply to Re: bupe is still out there, right? pseudoname, posted by SLS on April 22, 2006, at 14:52:24

> How do you administer buprenorphine? Route, dosage, schedule?

In my 5th month on bupe, I take:

Subutex 0.5mg sublingual tablet (Actually, I put it between the cheek & the gum, like chaw. Too much saliva under the tongue.)

I take the 0.5mg once or twice a day, depending on how the day is going. First dose anywhere from 5 AM to 10 AM; second dose 6-8 hours later.

But I had to get up to 1.0 mg, 3 times a day (6AM, 11AM, 4PM), in the first weeks, before I got the antidepressant benefit. For whatever reason, I just need less now.

I just posted a list of reported bupe doses I compiled last year, but it needs updating. Other Babblers have recently reported very small effective doses.

For anyone considering bupe, I think these may be good pages to show your doc. I hope he/she won't think a special DEA waiver is needed to Rx it for depression. (It isn't.)

When you first start, do NOT take more than 0.1 or 0.2mg a day. Larry Hoover gave me advice on taking such small doses:

The main reference is this:
J. Alexander Bodkin, MD, Gwen L. Zornberg, MD, Scott E. Lukas, PhD, and Jonathan O. Cole, MD. "Buprenorphine Treatment of Refractory Depression." Journal of Clinical Psychopharmacology, 1995, 15, pp. 49-57

I just posted my transcript of this study:
H.W. Emrich. "Antidepressant Effects of Buprenorphine." Lancet, 1982, Sep 25; 2(8300): 709

And there's this:
Enoch Callaway. "Buprenorphine for Depression: The Un-adoptable Orphan [Editorial]." Biological Psychiatry. 1996 Jun 15; 39(12):989-90.




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