Psycho-Babble Medication | about biological treatments | Framed
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Re: got em', thanks! }} answers

Posted by sdb on April 21, 2006, at 15:38:07

In reply to got em', thanks!, posted by saturn on April 20, 2006, at 18:21:19

> You metioned that atenolol probably has less >side effects than metoprolol. Are you >referring to CNS effects (depression, sedation)?

Yes for example. You will probably better on the atenolol. It's the "easier" drug pharmacologically.

> Do you know how nadolol compares in this regard (CNS penetration)?

Nadolol is not metabolized, is almost not found in the liquor cerebrospinalis (brain fluid), so there is only very minor penetration through brain-blood barrier.

> I am also curious how it is not a cardiodepressant. How is it that beta-1 blockade would not result in some cardiodepression. I assume atenolol and metoprolol *are* cardiodepressants? If so I would think nadolol would be best in terms of effects on my running.

There are some things that are too difficult to explain. But for running nadolol is probably the best one. Interestingly betablockers can even increase your endurance (slow, long distance running) but they will all decrease the maximum power due to less oxygen max. in the pathway. Note: Nadolol is hydrophil, does not penetrate blood-brain barrier, works 24h.
If you have performance anxiety and you consider to take a betablocker only in special situations you could also take a short actin oxprenolol, propranolol. For the longer term nadolol would be definately better. Nadolol resembles propranolol chemically, it has some other substituents which "likes" more the whater.
The metabolism is much easier than metoprolol for example.

It's a pleasure to answer these question. But I think I need some holidays from the p-babble :-)

kind regards





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