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EMSAM side effect info

Posted by RobertDavid on April 18, 2006, at 16:07:31

In reply to Re: agitation post from another board, posted by ravenstorm on April 18, 2006, at 9:26:36

Here is some info regarding side effects from one of the pre-approval trials.

Among 817 depressed patients who received EMSAM at doses of either 3mg/24hours (151 patients), 6mg/24hours (550 patients) or 6mg/24hours, 9mg/24hours, and 12mg/24hours (116 patients) in placebo-controlled trials of up to 8 weeks in duration, 7.1% discontinued treatment due to an adverse event as compared with 3.6% of 668 patients receiving placebo. The only adverse event associated with discontinuation, in at least 1% of EMSAM -treated patients at a rate at least twice that of placebo, was application site reaction (2% EMSAM vs. 0% placebo).

I think it's notable that only 3.5% more people stopped taking EMSAM than those taking a placebo. Also, application site reaction was the only side effect where the drop out rate was twice that of placebo. Hopefully those that experience some side effects will not be significant enough to have to stop taking EMSAM before being able to determine if it will work for them.

Everyone is so different. I have had such terrible side effects from other anti depressants like Wellbutrin, SSRI's, SNRI's and tricyclics, yet others do fine with them. As I've been posting, so far EMSAM is all benefit with no negative side effects. Just shows you that there's no making sence of which meds will or won't work for you. It's pretty much trial and error.





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