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Re: EMSAM-Day 5-Too early?? strugglingsteve

Posted by RobertDavid on April 12, 2006, at 19:52:52

In reply to Re: EMSAM-Day 5-Too early??, posted by strugglingsteve on April 12, 2006, at 19:25:45

> Where did you read about responses in 5 days? I may take longer and need a higher dose because I tried nardil and was at 45 mg for at least 2 and maybe 3 weeks and didnt get a response. I did read in one post on here that is about 5 years old from a dude named adam who was in the trials that it took him 5 weeks until it started to work for him. I worry that since nardil didnt work for me in that short trial that this wont but got to stay optimistic. I guess every drug is different. I am hoping that I only need the low dose patch so I dont have to worry about the diet. Man this gets complicated.....

I'll do some searching about the quick response time to EMSAM and post it when I find it.

If I go to higher doses I'm not likely to pay much attention to food interatctions. My doctor seems to think that the only reason there warnings at with the 30/40 mg patch is that BMS didn't spend money for studies to get it approved nor will that at this point. That by avoiding the gut it probably will not be an issue. Here's a blurb from BMS it mentioning "limiting data":

EMSAM is an irreversible MAO inhibitor. As a class, these compounds have been associated with
hypertensive crises caused by the ingestion of foods containing high amounts of tyramine. In its entirety, the data for EMSAM 6 mg/24 hours support the recommendation that a modified diet is not required at this dose. Due to the more limited data available for EMSAM 9 mg/24 hours and 12 mg/24 hours, patients receiving these
doses should follow Dietary Modifications Required for Patients Taking EMSAM 9 mg/24 hours and 12 mg/24 hours.

I'm not telling anyone not to follow the advise here, just that I feel that it won't be an issue and will probably eat what I want/don't anticipate issues should I go to higher patch doses. Rob




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