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Re: Is Valium more potent than Xanax? » ed_uk

Posted by zeugma on April 2, 2006, at 14:29:01

In reply to Re: Is Valium more potent than Xanax? » zeugma, posted by ed_uk on April 2, 2006, at 13:49:18

hello Ed,

this is something I didn't expect to find:

Eur Neuropsychopharmacol. 2003 Mar;13(2):129-34.


Clonazepam in the long-term treatment of patients with unipolar depression, bipolar and schizoaffective disorder.

Winkler D, Willeit M, Wolf R, Stamenkovic M, Tauscher J, Pjrek E, Konstantinidis A, Schindler S, Barnas C, Kasper S.

Department of General Psychiatry, University Hospital for Psychiatry, Wahringer Gurtel 18-20, A-1090, Vienna, Austria. dietmar.winkler@akh-wien.ac.at

The value of a long-term treatment with clonazepam in the prophylaxis of affective disorder is discussed controversially in the scientific literature. Altogether there are only a few reports on the use of this compound as a mood stabilizer, most of them describing patients suffering from bipolar affective disorder. The aim of this investigation was to evaluate clonazepam as a phase prophylactic medication in affective disorder. We conducted a retrospective chart review in 34 out-patients of our lithium clinic (15 suffering from unipolar depression, 15 from bipolar disorder, four from schizoaffective disorder), who had been treated with clonazepam as a long-term medication. Clonazepam was either given as monotherapy, or as in the case of lithium non-responders, as adjunctive therapy. Patients with unipolar depression had significantly (P=0.026) less depressive episodes after initiation of treatment with clonazepam. Patients with bipolar disorder did not benefit from this therapy. Neither manic/hypomanic phases nor depressive episodes were reduced in this group of patients. Interestingly, clonazepam also reduced affective phases in our four schizoaffective patients on a trend level. Our results indicate that patients with unipolar depression may benefit from a maintenance treatment with clonazepam. Due to methodological limitations our results need to be replicated in controlled double-blind randomized clinical trials.

>>>>>>>>>>>>>>>>>>>>>>>>>>>

nfortunately, there really is very little literature on clonazepam and depression, other than anecdotal reports here, in which I have seen far more frequent attributions of depression to clonazepam than to any of the other benzos. It is difficult to find literature on the possible antidepressant or depressant effects of other benzodiazepines other than alprazolam and adinazolam.

-z


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