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MAOI interaction with Trazodone

Posted by JaclinHyde on April 1, 2006, at 1:47:45

Sigh...guess what I found?

"Drug Interactions:
Trazodone may enhance the response to alcohol and the effects of barbiturates and other CNS depressants and patients should be cautioned accordingly.

Increased serum digoxin and phenytoin levels have been reported to occur in patients receiving trazodone concurrently with either of those 2 drugs. Little is known about the interaction between trazodone and general anesthetics; therefore, prior to elective surgery, trazodone should be discontinued for as long as clinically feasible.

****Because it is not known whether an interaction will occur between trazodone and MAO inhibitors, administration of trazodone should be initiated very cautiously with gradual increase in dosage as required, if an MAO inhibitor is given concomitantly or has been discontinued shortly before medication with trazodone is instituted.****

(And Tyler.....)

*****Trazodone may cause hypotension including orthostatic hypotension and syncope; caution is required if it is given to patients receiving antihypertensive drugs and an adjustment in the dose of the antihypertensive medication may be required.*****

Ambien CR has just become my new best friend :-)

JH


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poster:JaclinHyde thread:627393
URL: http://www.dr-bob.org/babble/20060329/msgs/627393.html