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Re: Tiagabine / Gabitril : Any experiences as AD, etc.

Posted by BIGDaddyachmed69 on March 1, 2006, at 22:38:16

In reply to Tiagabine / Gabitril : Any experiences as AD, etc., posted by River1924 on March 1, 2006, at 3:34:02

I've been off and on Gabitril for GAD, and it was a dud. The fact that my psychiatrist mentioned Gabitril as an alternative to benzodiazepines is laughable.

> I read the article below and was wondering if anyone had any experience with tiagabine? Thanks, River.
> Antiepileptic Tiagabine Promising for Anxiety and Depression
> Reuters Health Information 2006. 2006 Reuters Ltd.
> NEW YORK (Reuters Health) Feb 17 - Tiagabine, a selective inhibitor of gamma-aminobutyric acid (GABA), appears to be safe and effective for the treatment of patients with major depression with significant anxiety.
> Dr. Linda L. Carpenter and colleagues from Brown Medical School in Providence, Rhode Island report these findings in the January issue of the Journal of Clinical Psychiatry.
> In an 8-week, open-label study, 15 patients with "anxious depression" received tiagabine monotherapy, starting at 4 mg/day titrated for optimum response to a maximum of 20 mg/day.
> Six patients discontinued treatment before completing the full 8 weeks. In three patients this was due to poor tolerability, in two due to lack of effect and one patient was withdrawn due to a protocol violation.
> In the remaining nine patients, tiagabine significantly improved both depression and anxiety, as shown by a reduction from baseline in mean Hamilton Rating Scale scores. Overall, 33% of patients met criteria for remission of depression and 27% met criteria for remission of anxiety,
> The mean final daily dose of the agent was 12.5 milligrams and the most common side effects included dizziness, headache, and gastrointestinal upset.
> The results from this small open-label study are encouraging, the team concludes, "but data from larger placebo-controlled trials are needed to fully delineate the role of tiagabine in the treatment of patients with anxious depression."
> The study was funded by Cephalon, manufacturers of tiagabine.
> J Clin Psychiatry 2006;67:66-71.




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