Posted by yxibow on March 1, 2006, at 1:44:03
In reply to Re: The Truth Do SSRI's and SSNRI's Work For Anyon » Phillipa, posted by Chairman_MAO on February 28, 2006, at 21:49:06
> The only FDA-approved antidepressants that deserve that designation are the irreversible MAOIs.
> There are other drugs that do this as well, but most people consider them "drugs of abuse".
> In Goodman & Gilman's "Pharmacological Basis of Therapeutics", they state outright that the response rate of most antidepressants differs from placebo by the barest of margins. What this doctor said to you is reality.
Just because I am assuming you get benefit from MAOIs I gather -- the last resort of antidepressants, which have dangerous issues with diet, does not mean that the millions of people by now who have taken SSRIs have not gotten at least some relief from them.
By drugs of abuse, It would assume you're referring to the 19th century idea of using opiates to cure depression, which would verge on the edge of a practitioner losing their DEA license (yes, I know about the Oxycodone experiment on this board and I wish the individual well).
Antidepressants are tested in Phase trials that compare them to other antidepressants and p values . If their p value doesn't come within a statistical range, the Phase trials are usually halted.
I dont mean to insult you, but the statement seems to come out of left field. Not every antidepressant is right for every person. But I know of many people who have been helped by SSRIs.
We can all go back and forth bantering on this issue, but it does a disservice I think to those who are currently being helped by SSRIs on this board. I'm sure this won't be the last posting.
And I do agree with one of the earlier posts -- some people benefit greatly with minor augmentation of SSRIs with mild atypical antipsychotics.
Tidings and no bad feelings meant